Cefotaxime Sodium

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Products Details

 
Product name Cefotaxime Sodium   vgavbeas
CAS:
  • 64485-93-4
MF:
  • C16H16N5NaO7S2
MW:
  • 477.45
EINECS: 264-915-9
  • Cefotaxime (Claforan) was the first third-generationcephalosporin to be introduced. It possesses excellentbroad-spectrum activity against Gram-positive and Gramnegativeaerobic and anaerobic bacteria. It is more activethan moxalactam against Gram-positive organisms. Manyβ-lactamase–producing bacterial strains are sensitive to cefotaxime,including N. gonorrhoeae, Klebsiella spp., H. influenzae,S. aureus, and E. cloacae. Some, but not all,Pseudomonas strains are sensitive. Enterococci and Listeriamonocytogenes are resistant. The syn-isomer of cefotaxime is significantly more activethan the anti-isomer against β-lactamase–producing bacteria.This potency difference is, in part, because of greaterresistance of the syn-isomer to the action of β-lactamases.The higher affinity of the syn-isomer for PBPs, however,may also be a factor. Cefotaxime is metabolized in part to the less active desacetylmetabolite. Approximately 20% of the metaboliteand 25% of the parent drug are excreted in the urine. Theparent drug reaches the cerebrospinal fluid in sufficient concentrationto be effective in the treatment of meningitis.Solutions of cefotaxime sodium should be used within 24hours. If stored, they should be refrigerated. Refrigerated solutionsmaintain potency up to 10 days.
structural formula:Cefotaxime Sodium SterileProduct details are as follows:  
Appearance: white or white with a yellowish tinge powder
Solubility:  freely soluble in water, sparingly soluble in methanol
Specific optical rotation: +58 º~ +64 º
Specific absorbance: 360~390
Colour of solution:  ≤0.2
Loss on dry: ≤3.0%
PH: 4.5~6.5
Assay of cefotaxime:  916μg /mg~964μg/mg
Related substance:
Individual impurity: ≤1.0%
Total impurity: ≤3.0%
Function:
  1. Cefotaxime sodium sterile is a third-generation semi-synthetic cephalosporin with strong bactericidal activity against Gram-negative bacteria, especially on. Enterobacter. As for Escherichia coli, influenza bacillus, Klebsiella pneumonia, Proteus mirabilis, and Salmonella, it has stronger effect than Cefoperazone.
  2. It is used for infection of respiratory tract, urinary tract, bone and joint, skin and soft tissue, abdominal cavity, biliary tract, digestive tract, facial features, genitals and other parts caused by sensitive bacteria. It is also effective for infections caused by burns and trauma, as well as sepsis and central infection.
Our other major products: Cefotaxime Sodium Sterile Cefotaxime Sodium Sterile Cefotaxime Sodium Sterile

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